Plain PLGA particles can be used for testing system compatibility in drug delivery research. MTT assay revealed that dual-drug loaded PLGA nanoparticles exhibited a higher anticancer effect, compared to a bare mixture of two drugs in DMSO (having no PLGA). Your story matters Citation Cheng, J, Cheng, J, B. Teply, I Sherifi, J. Poly(ethylene glycol)–poly(lactic-co-glycolide) (PEG–b-PLGA) diblock copolymer micelles represent one of the most promising platforms for drug delivery, where the hydrophobic PLGA core can efficiently encapsulate many therapeutic agents, while the hydrophilic PEG shell prevents the adsorption of proteins and phagocytes, thus extending the blood circulation periods . Methods: RHT-loaded PLGA NPs were prepared using interfacial polymer deposition, following solvent displacement method with different ratios of polymer: Drug. They offer Drug Delivery, 2010; 17(8): 561–572 PLGA NPs have been used extensively to deliver immunomodulators and ... B., Gremião, M. P. D. & Chorilli, M. Nanotechnology-based drug delivery systems for the treatment of Alzheimer’s disease. Abstract The concept of PLGA-lipid hybrid nanoparticles arose as a motivation for developing drug delivery systems with versatile physical and chemical properties, unequivocal therapeutic benefits and minimized side effects. It was encapsulated in polysorbate 80 coated nanoparticles and intravenously injected. PLGA–PEG nanoparticles for in vivo targeted drug delivery The Harvard community has made this article openly available. showed that the lectin-modified PLGA nanoparticle encapsulated with basic fibroblast growth factor enhanced drug delivery to the brain, supporting the role of the PLGA NP-based drug delivery system for CNS disorders. After preparation, the detailed physicochemical char-acterization of the nanoparticles was performed, and the most highly loaded drug delivery … Background: Ischemia/reperfusion (I/R) injury causes the generation of many ROS such as H 2 O 2 and leads … We are keen, passionate & hardworking, committed to providing practical, innovative, and elegant solutions to customers in many countries/regions across the globe to meet the complex requirement of various … While PLGA-PEG di-block (15% PEG) formulation showed significantly higher 4T1 cellular uptake than all other formulations, there was no statistical difference in cellular uptake among PLGA, PLGA-PEG-PLGA tri-block (10% PEG), PLGA-PEG di-block (5% PEG) and PLGA-PEG di-block (10% PEG) nanoparticles. Nanoparticles represent drug delivery systems suitable for most administration routes. dependent cellular uptake and drug delivery profiles. Fluorescent nanoparticles and microspheres can be used in imaging and diagnostic applications for the detection of binding events or signal enhancement. The Development and Mechanism Studies of Cationic Chitosan-Modified Biodegradable PLGA Nanoparticles for Efficient siRNA Drug Delivery Pharmaceutical Research, 2010 Xudong Yuan 2017 The Author(s). The objective of PNPs in drug delivery applications is to achieve drug release in a controlled manner; to be biocompatible with tissues and cells; to reach higher Kaining Zhi Plough Center for Sterile Drug Delivery Solutions, University of Tennessee Health Science Center, 208 South Dudley Street, Memphis, TN 38163, USA. Sung, F. Gu, E. Levynissenbaum, A. Radovicmoreno, R. Langer, and O. Farokhzad. These particles are widely used for the internalization of drugs for cancer treatment. a new drug delivery system containing gentamicin. Drug loaded polylactide-co-glycolide (PLGA) nanoparticles shows long-term stability and target only infected cells without harming the normal cells. Focused on Polymeric Nanoparticles Production. Furthermore, multiple studies demonstrate that PLGA can easily be formulated into the drug carrying devices at all scales, i.e., as nanospheres, as microspheres and even as millimeter sized implants, can encapsulate a wide range of drugs, peptides or proteins and can be delivered over different periods of time with diverse routes of delivery. Surface Modification of Nanoparticles for Targeted Drug Delivery pp 33-71 | Cite as. Poly (lactic-co-glycolic acid) (PLGA) nanoparticles for drug delivery. Dual-Layer Surface Coating of PLGA-Based Nanoparticles Provides Slow-Release Drug Delivery To Achieve Metronomic Therapy in a Paclitaxel-Resistant Murine Ovarian Cancer Model. These drugs have an affinity for brain tumors and can be used as a drug carrier for the treatment of glioma such as mesenchymal stem cells (MSCs). PLGA-PEG based nano drug-delivery exhibits sustained release and activity. Drug Deliv, 2017; 24(1): 443–451! The system proposed was based on PLGA 85:15 and was produced by the double emulsification technique. Rev. a new drug delivery system containing gentamicin. This can reduce the toxicity and therefore the side effects thereof. ALANI3, GLEN S. KWON3, and JOSEPH R. ROBINSON3 1Department of Pharmaceutical Sciences, Drake University, Des Moines, Iowa 50265 2Pharmaceutical Chemistry, The University of Kansas, Lawrence, Kansas 66047 3Department of Pharmaceutical … Nanoparticle technology for drug delivery, volume 159 by Ram B Gupta. PLGA Nanoparticle-Based Formulations to Cross the Blood-Brain Barrier for Drug Delivery: From R&D to cGMP. Viability was determined by means of a WST assay, wherein cell viability of greater than 75% was observed for both PLGA and amorphous fumed silica particles and ferrous oxide, but was significantly reduced for zinc oxide particles. Curcumin (Cur) as a chemotherapeutic agent was encapsulated into PLGA NPs, and used to synthesize the PLGA (Cur)@PPy NPs. Nanomedicines can be used for a variety of cancer therapies including tumor-targeted drug delivery, hyperthermia, and photodynamic therapy. In order to overcome the disadvantage of drug burst release, chitosan (CS) was used to modify the PLGA nanoparticles. PLGA NANOPARTICLES WITH EXCELLENT PROPERTIES FOR DRUG DELIVERY: INVESTIGATION OF KEY PARAMETERS Jana GHITMAN1, Raluca STAN2, Horia IOVU3 Biodegradable polymers are materials used in multiple applications including biomedicine, nanomedicine and medical engineering. Handbook of Nanoscience, Engineering, and Technology, 2007. 2007. Your story matters Citation Cheng, J, Cheng, J, B. Teply, I Sherifi, J. Drug Deliv, 2017; 24(1): 443–451! To further improve the curative effect, D-α-tocopheryl poly(ethylene glycol) 1000 succinate (TPGS or Vitamin E TPGS) was added to form FA-F87-PLGA… For example, in the drug delivery field, nanoparticles can be synthesized from block copolymers such as PLGA and liposomes, which are the most commonly used biodegradable materials for the delivery of both hydrophilic and hydrophobic compounds. 63, 170–183 (2011).Crossref, Medline, CAS, Google Scholar; 107 Kocbek P, Obermajer N, Cegnar M, Kos J, Kristl J. This was a huge breakthrough in the nanoparticle drug delivery field, and it helped advance research and … Amongst the various drug delivery vehicles, polymeric nanoparticles have drawn major attention because of higher stability and the ability to be freeze-dried for long-term storage and be more chemi-cally and physically stable (Li et al., 2003). The selected uncoated nanoparticles consisted of 1:15 drug-PLGA weight ratio using 20 mg diosmin and methylene chloride as an organic phase because they showed the highest EE% (75.30±2.60%) and particle size with 0.10% w/v were further investigated in comparison with the selected uncoated PLGA nanoparticles. Selective intracellular delivery of PLGA-NPs or HA-PLGA-NPs against ovarian tumor cells. The preparation, properties and potential applications in drug delivery of biocompatible and biodegradable PLA-PEG and PLGA-PEG nanoparticles are discussed. Recent studies showed that the application of cell-modified nanoparticles for drug delivery system is an effective method to encourage the drugs to pass through for drug delivery. The obtained F-PLGA compounds were proven to form in aqueous solution colloidal stable nanoparticles (NPs) displaying a strong 19 F NMR signal. Size range for polymeric nanoparticles is about 10–1000 nm [ 28] and can be modified with different ligands such as antibodies to create a smart targeting delivery system. Over several decades, poly (lactic-co-glycolic acid) (PLGA) have been widely used as Micro-and Nano-carriers of therapeutic agents for drug delivery applications. Poly (lactic-co-glycolic acid) (PLGA) is one of the most commonly used biodegradable synthetic polymer to generate biocompatible nanoparticles since it is a US FDA* and EMA**-approved platform to the delivery of drugs in humans. I. INTRODUCTIONDrugs do not deliver themselves.¹ For a molecule to reach the target site from the site of administration in suffi cient concentration, and to maintain therapeutic levels for a suffi cient period of time, a delivery system is needed. Handbook of Nanotechnology,Springer,3rd edition. The results suggest that entrapment of paclitaxel in nanoparticles significantly increases the brain drug … Targeted delivery of cisplatin to prostate cancer cells by aptamer functionalized Pt(IV) prodrug-PLGA–PEG nanoparticles Shanta Dhara, Frank X. Gub,c, Robert Langerb,c,d,e, Omid C. Farokhzadc,f,1, and Stephen J. Lipparda,d,1 Departments of aChemistry and bChemical Engineering, cMIT-Harvard Center for Cancer Nanotechnology Excellence, dKoch Institute for Integrative Cancer Published by Informa UK Limited, trading as Taylor & Francis Group. PLGA nanoparticles for calcitriol delivery. Poly (lactic-co-glycolic acid) nanoparticles (PLGA NPs) are well recognized as an ideal drug delivery carrier for their biocompatibility and biodegradability. 126 – 128 The PLGA is biodegradable and could strongly attached at … Poly(lactide-co-glycolide)-based Micro and Nanoparticles for the Controlled Drug Delivery of Vitamins Magdalena Stevanovi 1,*, Dragan Uskokovi 1 1Institute of Technical Sciences of the Serbian Academy of Sciences and Arts, 11000 Belgrade, Serbia Zhang et al. 2007. Objectives: The present study described the use of Poly-lactic-co-glycolic acid (PLGA) nanoparticles (NPs), as effective delivery vehicles, to improve the therapeutic efficiency of RHT. Please share how this access benefits you. References Encyclopedia of Nanoscience and Nanotechnology, 2004, v.1 & 7. Poly(DL-lactide-co-glycolide); 50:50; IV 0.55-0.75 dL/g; Drug delivery (nanoparticles, ovalbumin, Type 2 Herpes Simplex Virus glycoprotein D); C57BL/6 mice; Controlled delivery of stromal derived factor-1alpha from poly lactic-co-glycolic acid core-shell particles to recruit mesenchymal stem cells for … Drug Del. Nanoparticle-mediated drug delivery is a promising approach for the delivery of various drug types to the site of disease in an effort to improve efficacy. of using nanotechnology-based drug delivery systems for effective eradication of mycobacterial infections. Marimuthu M, Bennet D, Kim SH. Formulation feasibility, process development and scale-up, formulation characterization, analytical and nonclinical services. Liposomes Production. By using PLGA- b -PEG nanoparticles with PSMA targeting aptamers (Apt) on the surface as a vehicle for the platinum(IV) compound c,t,c -[Pt(NH3)2(O2CCH2CH2CH2CH2CH3)2Cl2] ([1][1]), a lethal dose of cisplatin was delivered specifically to prostate cancer cells. Uniform structure and sustained release of Cu Abstract: Calcitriol, the active metabolite of Vitamin D3, is a potential anticancer agent but exhibits several drawbacks. We demonstrate that carboplatin loaded PLGA nanoparticles offer substantial enhancements over free drug in terms of increased tumour cytotoxicity at lower infused concentrations, reduced neurotoxicity and increased tissue retention. Multifunctional PLGA-based nanoparticles as a controlled release drug delivery system for antioxidant and anticoagulant therapy. Nanoparticles-based drug delivery systems have considerable potential for the treatment of tuberculosis (TB). B, CD44-mediated intracellular delivery of HA-PLGA-NPs in ovarian tumor cells. 2013;45:202–9. Keywords:Pluronic F87, TPGS, PLGA, nanoparticles, targeted drug delivery systems, paclitaxel. nanoparticles (NPs) such as poly (lactic-co-glycolic acid) (PLGA) NPs as drug carrier. A series of PLGA polymers with different molar feed ratios (P2:87/13, P3:83/17, P5:63/37, P6:76/24, P9:53/47) were synthesized by direct melt poly condensation method. Poly (lactic-co-glycolic acid) (PLGA) is one of the most effective biodegradable polymeric nanoparticles (NPs). the above objectives. Therefore, PLGA nanoparticles can be used as an effective carrier to deliver the two hydrophobic drugs to MDA-MB-231 breast cancer cells, for a superior anticancer effect. PLGA nanoparticles. Plain PLGA microspheres and nanoparticles can be used in drug delivery research and formulation as control agents or can be used to test system compatibility before loading an API into the carrier. Please share how this access benefits you. This study aimed to investigate the efficacy of encapsulating therapeutic molecules in poly lactic/glycolic acid (PLGA) nanoparticles for drug delivery to the cochlea. Rel. Abstract: Introduction: Polymeric nanoparticles provide a promising strategy for site-specific delivery of dietary phytochemicals in the treatment of colon cancer. DOI: 10.1080/10717544.2016.1261381 ORIGINAL ARTICLE PLGA nanoparticles for the oral delivery of nuciferine: preparation, physicochemical characterization and in vitro/in vivo studies It has been approved by the US FDA to use in drug delivery systems due to controlled and sustained- release properties, low toxicity, and biocompatibility with tissue and cells. To cross the BBB, surfactant-coated polymeric nanoparticles of drug should be of ≤300 nm [ 29 ]. Study design An experimental study. PLGA nanoparticles in the ocular drug delivery The topical ocular administration of drugs has two different purposes: to treat superficial eye diseases, such as infections (e.g. #Microspheres and #Nanoparticles for Drug Delivery Nomisma Healthcare is one of the world's leading specialty polymer companies, serving customers in a variety of pharmaceutical markets. PLGA Nanoparticles in Drug Delivery: The State of the Art. Drug delivery using nanoparticle was previously successfully used for cancer Background. To achieve predictable and clinically relevant volumes of drug distribution, nanoparticle size, surface charge, and especially composition and structure must be controlled. These phenomena altogether make FLT loaded NPs as a potential drug delivery system for treatment of prostate cancer. The system proposed was based on PLGA 85:15 and was produced by the double emulsification technique. In this study, we investigated the possibility of using it in allergen immunotherapy. Especially, PLGA In our polymer system, we found that drug loadings of 1% minimized NP polydispersity, and thus these NPs … Itxaso Garcia-Orue, Jose Luis Pedraz, Rosa Maria Hernandez, Manoli Igartua, Nanotechnology-based delivery systems to release growth factors and other endogenous molecules for chronic wound healing, Journal of Drug Delivery Science and Technology, 10.1016/j.jddst.2017.03.002, 42, (2-17), (2017). Abstract:Aim: Folate-conjugated Pluronic F87-poly(lactic-co-glycolic acid) block copolymer (FA-F87-PLGA) was synthesized to encapsulate anticancer drug Paclitaxel (PTX) for targeted drug delivery. The hydroxyl terminated PLGA (uncapped) nanoparticles have a drug incorporation efficiency of more than 30% as compared to only 10% with methyl terminated PLGA (capped) nanoparticles. PLGA has a number of advantages over other polymers used in drug and gene delivery including biodegradability, biocompatibility, and approval for human use granted by the U.S. Food and Drug Administration. Hen egg-white lysozyme (HEL) was used as a model antigen. The application of nanoparticles from a biodegradable polymer such as PLGA, improves solubility, the retention time and efficiency in drug delivery for therapeutic purposes. Core–shell PLGA@Polypyrrole nanoparticles (PLGA@PPy NPs) were prepared by polymerization of pyrrole on the surface of PLGA nanoparticles (PLGA NPs). FLT was in the amorphous form in the nanoparticles. Curcumin (CU) is a dietary phytochemical with well-proven anti-cancer activity in colon cancer. 2. We determined the in vitro efficacy of the nanoparticle system by evaluating the release kinetics of short-lived dye (30 mins), nile red, from PLGA-PEG nanoparticles by quantifying the absorption of released dye at 525 nm. Polym J. The drug used was hexapeptide dalargin, an anti-nociceptive peptide that cannot cross the BBB alone. Since there have been many difficulties in clinical administration of anticancer drugs due to their poor solubility & targeting, development of new biodegradable Nano-carriers can provide good solutions to overcome the most of recent problems to obtain a better controlled release and targeted delivery of drugs with better efficiency and less side-effects. Prolonged drug release with similar AUC, high Vd, and clearance with the CβG-PLGA blends suggests that the blended nanoparticles could be ideal candidates for in vivo delivery of toxic drugs to achieve similar therapeutic effect of pure drug with better efficacy and safety. DOI: 10.1080/10717544.2016.1261381 ORIGINAL ARTICLE PLGA nanoparticles for the oral delivery of nuciferine: preparation, physicochemical characterization and in vitro/in vivo studies
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